Hexarelin — EU research guide.
Hexarelin (Examorelin) is a synthetic hexapeptide GH secretagogue and ghrelin receptor agonist. It is the most potent GHS-R1a agonist among the classic GHRP peptides and additionally demonstrates direct cardioprotective effects independent of GH release.
What is Hexarelin?
Hexarelin is a synthetic hexapeptide with a 2-methyltryptophan substitution that confers high affinity for GHS-R1a. It produces the most potent GH pulse of the GHRP class but also causes the most pronounced cortisol and prolactin responses. Its direct cardiac effects — mediated through non-GHS-R mechanisms including CD36 — make it a compound of interest in cardiovascular research beyond its GH effects.
What does the research show?
Human studies confirm potent GH release with desensitisation upon repeated dosing — a characteristic that limits sustained use research. Cardiac research: in rat ischaemia-reperfusion models, hexarelin reduced infarct size and improved contractile function via a GH-independent mechanism (CD36 receptor). The cardioprotective profile is a distinct research angle compared to other GHRPs.
EU legal status
Not approved in the EU. WADA-prohibited (S2). Available for laboratory research only.
Molecular information
Pharmacokinetics
Hexarelin across EU suppliers
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Frequently asked questions
What is Hexarelin? ▾
Hexarelin is a synthetic hexapeptide with a 2-methyltryptophan substitution that confers high affinity for GHS-R1a. It produces the most potent GH pulse of the GHRP class but also the most pronounced cortisol and prolactin responses.
Why is Hexarelin studied in cardiovascular research? ▾
It has direct cardiac effects mediated through non-GHS-R mechanisms including the CD36 receptor, making it of interest beyond its GH effects.
What does the research show? ▾
Human studies confirm potent GH release with desensitisation on repeated dosing, and in rat ischaemia-reperfusion models it reduced infarct size and improved contractile function via a GH-independent CD36 mechanism.
Why does Hexarelin's effect diminish with repeated use? ▾
Human studies show desensitisation upon repeated dosing, a characteristic that limits sustained-use research.
Is Hexarelin legal in the EU? ▾
It is sold as a research compound for laboratory use only.
Is Hexarelin banned in sport? ▾
Yes. It appears on the WADA prohibited list (S2).