PeptideCompareMitochondrial — Support
Mitochondria produce cellular energy, and mitochondrial dysfunction is studied as a feature of aging. This topic covers compounds studied for mitochondrial function, efficiency and biogenesis.
Compounds studied for mitochondrial function
CoQ10 / Ubiquinol. Coenzyme Q10 (ubiquinone) and its reduced form ubiquinol are electron carriers in the mitochondrial respiratory chain. Levels decline with age and are lowered by statin use.
MitoQ. CoQ10 attached to a carrier molecule that concentrates it inside mitochondria. It has been studied as a mitochondria-targeted antioxidant.
SS-31 (Elamipretide). A mitochondria-targeted tetrapeptide that binds cardiolipin, a key lipid of the inner mitochondrial membrane.
MOTS-c. A peptide encoded in mitochondrial DNA. Preclinical studies report AMPK activation and effects on insulin sensitivity.