SS-31 (Elamipretide) — the cardiolipin protector.
SS-31 (Elamipretide, MTP-131) is a mitochondria-targeting tetrapeptide that selectively concentrates in the inner mitochondrial membrane, binding cardiolipin to stabilise energy production. It has advanced furthest in clinical trials of the mitochondrial peptides.
What is SS-31 (Elamipretide)?
SS-31 is a synthetic tetrapeptide that crosses cell membranes and concentrates 1000-5000x in the inner mitochondrial membrane, where it binds cardiolipin — a phospholipid essential for the electron transport chain. By stabilising cardiolipin, SS-31 improves mitochondrial efficiency and reduces reactive oxygen species. It has been studied clinically (as Elamipretide) for mitochondrial diseases, heart failure and rare conditions like Barth syndrome.
What does the research show?
What to look for when buying in Europe
One of the more clinically advanced peptides in this category. Require ≥98% HPLC purity and a batch-matched COA from a named lab. PeptideCompare tracks several EU vendors.
Molecular information
Pharmacokinetics
Compare SS-31 (Elamipretide) across EU suppliers
6 EU vendors · COA-verified · from €39.95 · Updated monthly
Frequently asked questions
What is SS-31 (Elamipretide)? ▾
SS-31 is a synthetic tetrapeptide that crosses cell membranes and concentrates in the inner mitochondrial membrane, where it binds cardiolipin, a phospholipid essential for the electron transport chain. Stabilising cardiolipin improves mitochondrial efficiency and reduces reactive oxygen species.
What does the research show? ▾
There is strong mechanistic and animal evidence for cardiolipin stabilisation and improved ATP production, and it reached late-stage clinical trials, as Elamipretide, for heart failure and Barth syndrome with mixed primary-endpoint results.
How does SS-31 protect mitochondria? ▾
By concentrating in the inner mitochondrial membrane and binding cardiolipin, it stabilises the electron transport chain, improving efficiency and lowering reactive oxygen species.
Is SS-31 the same as Elamipretide? ▾
Yes. SS-31 is also known as Elamipretide (MTP-131), the name under which it has been studied clinically.
What conditions has SS-31 been studied for? ▾
It has been studied clinically for mitochondrial diseases, heart failure and rare conditions such as Barth syndrome, with mixed clinical results.
Is SS-31 legal in the EU? ▾
It is sold as a research compound for laboratory use only.