PeptideCompareCJC-1295 (No DAC) — the GH pulse GHRH.
CJC-1295 without DAC (Drug Affinity Complex) is a modified GHRH analogue with a short half-life of ~30 minutes, designed to mimic the natural pulsatile pattern of GH release. It is almost always stacked with Ipamorelin — the combination is the most widely-researched GHRH/GHRP pairing in EU research use.
No DAC vs With DAC — the key difference
CJC-1295 With DAC (Drug Affinity Complex) has a half-life of 6–8 days due to albumin-binding chemistry added to the C-terminus. This creates a sustained, blunted GH elevation — more like a constant background raise than a natural pulse. CJC-1295 Without DAC has a half-life of ~30 minutes and creates a GH pulse that mirrors natural release patterns. Most researchers prefer No DAC for pulse mimicry; With DAC for convenience (less frequent injection). PeptideCompare tracks both across EU vendors.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ Modelled per compound from molecular structure — chain length, cyclisation, oxidation- and deamidation-prone residues and light sensitivity. Indicative only, not lab-measured per batch.
Compare CJC-1295 (No DAC) across EU suppliers
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Frequently asked questions
What is CJC-1295 without DAC? ▾
CJC-1295 without DAC is a GHRH analog, also called Modified GRF(1-29), with a half-life of about 30 minutes that creates a GH pulse mirroring natural release patterns.
What is the difference between No DAC and With DAC? ▾
With DAC has a 6 to 8 day half-life from albumin-binding chemistry, giving a sustained but blunted GH raise, whereas No DAC has a roughly 30-minute half-life and produces natural-style pulses. Researchers generally prefer No DAC for pulse mimicry and With DAC for convenience.
What does the research show? ▾
There is moderate evidence for pulsatile GH release via GHRH-receptor stimulation, a well-established mechanism, but limited direct clinical-outcome data, since most human data derive from the parent GRF(1-29) or sermorelin.
Why do researchers prefer No DAC? ▾
Its short half-life produces short, physiological GH pulses that more closely mirror natural release, which many researchers prefer over the sustained pattern of the DAC version.
Is CJC-1295 No DAC legal in the EU? ▾
It is sold as a research compound for laboratory use only.
Why is it also called Modified GRF(1-29)? ▾
CJC-1295 No DAC is a modified version of GRF(1-29), the sermorelin fragment, with amino-acid substitutions that improve stability while keeping the roughly 30-minute half-life and natural pulse profile.
References
- The human study behind the numbers on this page: two randomised, placebo-controlled ascending-dose trials in healthy adults. A single injection raised GH 2–10× for 6+ days and IGF-1 1.5–3× for 9–11 days; the estimated half-life was 5.8–8.1 days. One of very few GHRH analogues with published human PK. Teichman SL, et al. J Clin Endocrinol Metab. 2006;91(3):799–805. DOIPubMed 16352683