Selank — the anxiolytic heptapeptide.
Selank is a synthetic heptapeptide analogue of the immunomodulating peptide tuftsin, developed and registered in Russia for anxiety and generalised anxiety disorder. Unlike benzodiazepines, it is non-addictive and does not cause sedation at research doses.
How Selank reduces anxiety
Selank modulates GABAergic activity (like benzodiazepines) but without causing tolerance or dependence. It also upregulates expression of BDNF and affects serotonin metabolism. The dual anxiolytic + immune-modulating profile is unusual — tuftsin itself is a natural immune peptide, and Selank retains this property while adding CNS effects.
Molecular information
Pharmacokinetics
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Nasal spray and injectable · COA-verified EU vendors
Frequently asked questions
What is Selank? ▾
Selank is a synthetic heptapeptide analog of the immune peptide tuftsin (sequence TKPRPGP), developed in Russia and registered there for anxiety. It is studied as an anxiolytic and immune-modulating peptide.
How does Selank reduce anxiety? ▾
It modulates GABAergic activity in a way similar to benzodiazepines but without causing tolerance or dependence, and it also upregulates BDNF and affects serotonin metabolism.
What does the research show? ▾
There is strong evidence for anxiety reduction, as a registered drug in Russia with trials showing anxiolytic effects without sedation or dependence, and moderate evidence for immune modulation and for cognitive effects under stress.
Is Selank addictive? ▾
Published research reports anxiolytic effects without the tolerance or dependence associated with benzodiazepines, though completed EU clinical trials are lacking.
Is Selank legal in the EU? ▾
It is a registered drug in Russia but is not approved in the EU, where it is sold as a research compound for laboratory use only.
How is Selank different from Semax? ▾
Both are Russian heptapeptides that upregulate BDNF, but Selank is a tuftsin analog studied mainly for anxiety and immune modulation, whereas Semax is an ACTH analog studied mainly for neuroprotection and cognition.