PeptideCompareDSIP — Delta Sleep-Inducing Peptide.
DSIP is a naturally occurring nonapeptide first isolated from the cerebral venous blood of sleeping rabbits in 1977. Despite its name, its effects on sleep in research have been more nuanced than the name implies.
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid peptide that crosses the blood-brain barrier. It was named for its association with delta-wave (deep) sleep, though its actual mechanism remains poorly understood. Research interest spans sleep regulation, stress resilience, and modulation of various neuroendocrine systems.
What does the research show?
What to look for when buying in Europe
One of the most affordable peptides on PeptideCompare. As a short stable peptide, purity should be high — require ≥98% HPLC and a batch-matched COA.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ Computed from molecular properties (sequence length, cyclisation, residues prone to oxidation or deamidation, light sensitivity), per compound. Indicative only — not lab-measured per batch.
Compare DSIP across EU suppliers
11 EU vendors · COA-verified · from €18.85 · Updated monthly
Frequently asked questions
What is DSIP? ▾
DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid peptide that crosses the blood-brain barrier. It was named for its association with delta-wave (deep) sleep, though its actual mechanism remains poorly understood.
What does the research show? ▾
The evidence is limited across the board: sleep-architecture studies show mixed results, animal data suggest stress-buffering and cortisol modulation, and pain and antioxidant signals are preliminary and inconsistent.
Does DSIP actually improve sleep? ▾
Results are mixed. Some studies show improved sleep onset and quality while others find minimal effect, and the mechanism is unclear.
Why is DSIP still poorly understood? ▾
Despite decades since its 1977 discovery, its mechanism remains unclear and the evidence base is limited and inconsistent.
Does DSIP affect stress and cortisol? ▾
Animal data suggest stress-buffering and cortisol-modulating effects, but this remains preliminary and unconfirmed in humans.
Is DSIP legal in the EU? ▾
It is sold as a research compound for laboratory use only.
References
- The isolation paper: DSIP was purified from the cerebral venous blood of rabbits given hypnogenic thalamic stimulation and its sequence determined as Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. The synthetic nonapeptide and several fragments were then infused intraventricularly in rabbits under double-blind conditions. Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M. Pflugers Arch. 1978;376(2):119–129. DOIPubMed 568769
- The honest counterweight: a 2006 review argues the DSIP-sleep link has never been firmly established. The sequence was determined only once by older methods and not re-checked; DSIP-like immunoreactive material does not carry the DSIP sequence; and in the authors' own tests DSIP failed to influence sleep after 30 nmol given intraventricularly. Nearly all supporting work is preclinical. Kovalzon VM, Strekalova TV. J Neurochem. 2006;97(2):303–309. DOIPubMed 16539679
- One of the few human reports: an early study of acute and delayed effects of DSIP on human sleep behaviour. Human trials of DSIP for insomnia have been small and produced conflicting results, which is why the sleep claim remains unresolved. Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Int J Clin Pharmacol Ther Toxicol. 1981;19(8):341–345. PubMed 6895513