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Home / Encyclopedia / Neuro & Cognitive / N-Acetyl Selank
MONOGRAPH No. 084
SEQUENCE
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro
MW
793.9 Da
CAS
864070-44-0
EU STATUS
Research only
WADA
Not listed
MIN PURITY
≥98% HPLC
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🧠 Neuro & Cognitive

N-Acetyl Selank — EU research guide.

N-Acetyl Selank is an acetylated analogue of Selank (TBCE-Lys-Glu-Asp-Gly) with proposed enhanced bioavailability and more pronounced anxiolytic-nootropic effects compared to the parent compound.

Last reviewed:

What is N-Acetyl Selank?

N-Acetyl Selank modifies the parent Selank molecule with an acetyl group on the N-terminus, increasing lipophilicity and proposed membrane permeability. The mechanism of action mirrors Selank — modulation of GABAergic transmission, BDNF upregulation and IL-6 normalisation — but with claimed enhanced potency per dose.

What does the research show?

Research on N-Acetyl Selank is primarily preclinical and limited compared to the parent Selank, which has more established Russian clinical data. Animal studies suggest comparable or enhanced anxiolytic effects with potentially lower effective dose. Head-to-head human comparisons are absent from published literature.

EU legal status

Not approved anywhere. Available from EU research vendors as a laboratory compound. Same regulatory considerations apply as for Selank.

Limited independent research compared to parent Selank. Preclinical data only for the acetylated form. Not for human use. This is a research compound, not a medication.
✓ PeptideCompare lists N-Acetyl Selank from EU vendors. Confirm identity by mass spec — the acetyl modification must be verified separately from HPLC purity.

Molecular information

Molecular formula
C35H59N11O10
Molecular weight
793.9 Da
CAS number
864070-44-0

Pharmacokinetics

Half-life (t½)
≈ 4.17 h
Source: Terminal acetyl/amide extends to ~200–300 min

Potency retained over time

Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.

Freezer −20 °C
36+ mo
Stable · >95% potency
Fridge 4 °C
3-4 mo
In use · after recon
Room 20 °C
2-3 wks
Limited · moderate loss
Warm 37 °C+
2-3 days
Critical · rapid degradation

⚠ Estimates modelled per compound from its molecular properties (sequence length, cyclisation, oxidation- and deamidation-prone residues, light sensitivity). Indicative only — not lab-measured per batch.

N-Acetyl Selank across EU suppliers

COA-verified EU vendors · Updated monthly

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