Artikel
NAD+ — Precursors
NAD+ is essential for energy, DNA repair and sirtuin activation. It declines by up to 50% by age 50. These are the compounds that raise it back up.
THE PATHWAY AT A GLANCE
NMN
→
NR
→
NAM
→
NA (Niacin)
all convert to
NAD+
NMN — BEST EVIDENCE
★ RecommendedMost direct precursor. Strong human clinical trials. Dose: 500–1000mg/day in the morning. Quality varies — always verify COA purity and assay value.
Cost range: €60–120/month · Take with fat
NR — WELL STUDIED
One step before NMN in the pathway. Good safety profile, lower cost. Must convert to NMN then NAD+ inside cells. Patented form: Tru Niagen.
Cost range: €40–80/month · Good tolerability
NIACIN (NA) — CHEAPEST
Highly effective at raising NAD+. Very inexpensive. Major drawback: skin flushing at doses above 50mg. Slow-release forms reduce this. Clinically proven for decades.
Cost range: €5–15/month · Flushing side effect
NIACINAMIDE (NAM) — CAUTION
No flushing. Raises NAD+ but inhibits sirtuins at high doses — counterproductive for longevity. Best at low dose (250–500mg) alongside NMN, not as primary precursor.
⚠ Sirtuin inhibition at high dose
ARTICLES IN THIS HUB
NMN tablet vs NAD+ injection — why the precursor wins
8 min · Biosynthesis pathway step by step
All NAD+ precursors explained — NMN, NR, NA, NAM and more
10 min · Complete precursor comparison
NAD+ synergists — what stacks with NMN and why
9 min · Resveratrol, TMG, apigenin, quercetin