PEG-MGF — EU research guide.
PEG-MGF (Pegylated Mechano Growth Factor) is a PEGylated form of MGF, a splice variant of IGF-1 produced in mechanically stressed muscle. PEGylation extends its half-life from minutes to hours, enabling systemic circulation.
What is PEG-MGF?
MGF is produced locally in muscle fibres in response to mechanical load via alternative splicing of IGF-1 pre-mRNA. The native MGF peptide has a half-life of only a few minutes. PEGylation — attachment of polyethylene glycol chains — masks the peptide from proteolytic enzymes and immune recognition, extending the half-life to ~hours and allowing systemic distribution after injection.
What does the research show?
Animal studies show PEG-MGF activates muscle satellite cells, promotes myoblast proliferation and accelerates muscle repair after injury. The local/systemic distinction from IGF-1 LR3 makes it a complementary tool in muscle biology research. No human clinical trials. The anabolic potential has attracted significant doping research interest.
EU legal status
Not approved in the EU or anywhere. WADA-prohibited (S2). Available for laboratory muscle biology research only.
Molecular information
Pharmacokinetics
PEG-MGF across EU suppliers
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