N-Acetyl Semax — EU research guide.
N-Acetyl Semax is an acetylated analogue of Semax (ACTH 4–7 Pro-Gly-Pro) with proposed enhanced CNS penetration, longer duration of action and more pronounced BDNF-stimulating effects than the parent compound.
What is N-Acetyl Semax?
The acetylation of Semax's N-terminus increases its resistance to aminopeptidase degradation, extending the effective window of activity. The primary mechanism remains ACTH-receptor-independent BDNF and NGF upregulation in prefrontal cortex and hippocampus, with additional serotonergic and dopaminergic modulation.
What does the research show?
Like N-Acetyl Selank, direct clinical research on N-Acetyl Semax is sparse. The pharmacological rationale derives from acetylation studies on other neuropeptides showing improved stability. Comparative animal studies suggest enhanced and extended cognitive effects versus Semax at equivalent doses. No head-to-head human trials published as of mid-2026.
EU legal status
Not approved anywhere. Available from EU research vendors. Same considerations as parent Semax apply — most relevant Russian research concerns the non-acetylated form.
Molecular information
Pharmacokinetics
N-Acetyl Semax across EU suppliers
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