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Home / Encyclopedia / Other compounds / Bacteriostatic Water
MONOGRAPH No. 041
TYPE
Bacteriostatic diluent (water + benzyl alcohol)
PRESERVATIVE
0.9% (9 mg/mL) benzyl alcohol
PH
5.7 (4.5–7.0), label value
MW
108.14 g/mol (benzyl alcohol)
CAS
100-51-6 (benzyl alcohol)
EU STATUS
Vendor vial not verified
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Bacteriostatic Water — EU research guide.

Bacteriostatic water is sterile water containing benzyl alcohol as a bacteriostatic preservative, supplied in multiple-dose vials. It is not a peptide and has no pharmacological activity as a diluent; it is a different product from sterile water and from saline.

Last reviewed:

What is bacteriostatic water?

Bacteriostatic water for injection is sterile water containing a bacteriostatic preservative, benzyl alcohol. On the Hospira label for its 30 mL multiple-dose vial the strength is 0.9% (9 mg/mL), the pH is 5.7 (4.5 to 7.0) and the stated purpose is diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection; the 20 mL glass vial on the same label lists 1.1% (11 mg/mL). A bacteriostatic preservative inhibits bacterial growth; it does not replace sterility. The product differs from sterile water without preservative, which is single-use, and from bacteriostatic saline, which contains benzyl alcohol in 0.9% sodium chloride instead of water.

What does the research show?

No efficacy claims are made: as a diluent it is a vehicle, not a treatment. The safety literature concerns the preservative. A 1982 report in the New England Journal of Medicine (Gershanik) described a gasping syndrome in neonates linked to benzyl alcohol exposure from bacteriostatic solutions, and the current label states in capitals that the product is not for use in neonates because benzyl alcohol has been associated with toxicity in that population. On vial handling, CDC guidance says an opened multi-dose vial should be dated and discarded within 28 days unless the manufacturer states another date.

EU legal status

This page does not name a specific EU marketing authorisation for bacteriostatic water. A vial sold by a research vendor is not itself an authorised medicine unless it carries a marketing authorisation number; the sterility, grade, preservative content, labelling and Ph. Eur. or USP compliance of a specific vendor vial cannot be assumed from this page, so the COA and label of each listing should be read.

⚠ Not an active compound: the label states that it is not for use in neonates because benzyl alcohol has been associated with toxicity in neonates, a preservative does not make an unlicensed vial sterile, and the sterility and strength of vendor vials are not verified here. This is a research compound, not a medication.
✓ PeptideCompare compares bacteriostatic water listings from EU research vendors as a diluent product and shows COA status per supplier where available.

Molecular information

Composition
Water for injection with benzyl alcohol (preservative)
Preservative formula
C7H8O
Preservative molecular weight
108.14 g/mol
Preservative CAS number
100-51-6
Source: PubChem CID 244 (benzyl alcohol)

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Potency retained over time

Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.

Freezer −20 °C
n/a
Unopened · long shelf life
Fridge 4 °C
open: wks
Opened · use within weeks
Room 20 °C
open: wks
Stable · keep sterile
Warm 37 °C+
store cool
Keep cool · away from heat

⚠ Computed from molecular properties (sequence length, cyclisation, residues prone to oxidation or deamidation, light sensitivity), per compound. Indicative only — not lab-measured per batch.

Bacteriostatic Water across EU suppliers

COA-verified EU vendors · Updated monthly

References

  1. US label of bacteriostatic water: 0.9% (9 mg/mL) benzyl alcohol in 30 mL vials and 1.1% in 20 mL glass vials, pH 5.7 (4.5 to 7.0), not for use in neonates, storage at 20 to 25 °C. Bacteriostatic Water for Injection, USP (multiple-dose vial). DailyMed drug label, Hospira, Inc. Source
  2. Report of a gasping syndrome in neonates linked to benzyl alcohol. Gershanik J, Boecler B, Ensley H, et al. N Engl J Med 1982;307(22):1384-1388. DOI
  3. Injection-safety guidance: 28-day discard limit for opened multi-dose vials unless the manufacturer states otherwise. Centers for Disease Control and Prevention. Preventing Unsafe Injection Practices (Injection Safety). Source

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