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MONOGRAPH No. 013
TYPE
Polypeptide thymus extract
MW
Variable (mixture)
CAS
Various
EU STATUS
Research only (EU)
WADA
Not listed
MIN PURITY
Standardised by bioactivity
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⏳ Anti-Aging & Longevity

Thymalin — EU research guide.

Thymalin is a polypeptide extract from bovine thymus, used in Russian clinical practice since the 1980s as an immunomodulator. Research focuses on thymic function restoration, immune senescence and longevity.

Last reviewed:

What is Thymalin?

Thymalin is a complex preparation of low-molecular-weight polypeptides isolated from bovine thymus. Unlike synthetic single-sequence bioregulators, it is a mixture standardised by biological activity. It has been used as a registered drug in Russia for decades under the name Timalin. In the EU it has no registered pharmaceutical status.

What does the research show?

Russian longitudinal studies in elderly cohorts (some spanning 6–8 years) report reduced mortality, improved immune function markers (T-cell counts, NK activity) and slower immune senescence in thymalin-treated groups versus controls. A notable long-term study showed ~2.0x mortality reduction over 6 years in an elderly cohort. Western replication is absent; all evidence is Russian-origin.

EU legal status

Not approved in the EU as a medicine. Available as a research compound from specialist vendors. Note: being a biological extract, batch consistency is an important quality concern — ensure vendors provide bioactivity standardisation data.

All controlled trial data is from Russian studies. No Western regulatory approval. Biological extract — batch variability is relevant. Not for human use in the EU research context. This is a research compound, not a medication.
✓ PeptideCompare lists Thymalin from EU vendors. Request bioactivity standardisation data alongside any chemical purity documentation.

Molecular information

Molecular weight
Variable (mixture)
CAS number
Various

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Potency retained over time

Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.

Freezer −20 °C
36+ mo
Stable · >95% potency
Fridge 4 °C
3-4 mo
In use · after recon
Room 20 °C
10-13 days
Limited · moderate loss
Warm 37 °C+
2-3 days
Critical · rapid degradation

⚠ Computed from molecular properties (sequence length, cyclisation, residues prone to oxidation or deamidation, light sensitivity), per compound. Indicative only — not lab-measured per batch.

Thymalin across EU suppliers

COA-verified EU vendors · Updated monthly

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