PeptideCompareSermorelin — the original GHRH analogue.
Sermorelin is a GHRH analogue corresponding to the first 29 amino acids of growth hormone-releasing hormone — the shortest fully functional fragment. It stimulates the pituitary to produce and release its own growth hormone.
What is Sermorelin?
Sermorelin is GHRH(1-29), the biologically active fragment of growth hormone-releasing hormone. Because it works upstream — stimulating the pituitary rather than supplying GH directly — the body retains its natural feedback loop, which proponents argue is a more physiological approach than exogenous HGH. It was historically FDA-approved (as Geref) for diagnostic use before being discontinued for commercial reasons.
What does the research show?
What to look for when buying in Europe
Sermorelin is most-researched stacked with Ipamorelin. Fewer EU vendors carry it than newer GHRH analogues like CJC-1295. Require ≥98% HPLC purity and cold-chain-aware shipping.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ A structural estimate, derived from each compound's sequence length, cyclisation and oxidation-, deamidation- and light-sensitive residues. Indicative only — not lab-measured per batch.
Compare Sermorelin across EU suppliers
4 EU vendors · COA-verified · from €31.45 · Updated monthly
Frequently asked questions
What is Sermorelin? ▾
Sermorelin is GHRH(1-29), the biologically active fragment of growth hormone-releasing hormone. It stimulates the pituitary to release GH rather than supplying GH directly, so the body retains its natural feedback loop.
How is Sermorelin different from HGH? ▾
It works upstream by stimulating the pituitary, which proponents argue is more physiological than exogenous HGH because natural feedback regulation is preserved.
What does the research show? ▾
There is strong evidence for GH and IGF-1 elevation, historically used as a diagnostic agent for GH deficiency, moderate evidence for body-composition effects when stacked with a GHRP like ipamorelin, and limited support for anti-aging claims.
Why is Sermorelin often combined with a GHRP? ▾
Its very short half-life of a few minutes limits sustained effect, so it is often combined with a GHRP like ipamorelin, with some data on improved body composition and sleep quality.
Is Sermorelin legal in the EU? ▾
It was historically FDA-approved (as Geref) for diagnostic use before commercial discontinuation. In the EU it is sold as a research compound for laboratory use only.
Is Sermorelin banned in sport? ▾
Yes. It appears on the WADA prohibited list (S2).
References
- Short review of sermorelin, the first 29 amino acids of GHRH. It was FDA-approved (Geref) for diagnosing and treating childhood GH deficiency, then withdrawn for commercial — not safety — reasons; it survives through compounding pharmacies. Walker RF. Clin Interv Aging. 2006;1(4):307–308. DOIPubMed 18046908
- GHRH(1-29) twice daily raised the reduced GH and IGF-1 levels of older men — direct human evidence that the fragment engages the axis, rather than the inference from tesamorelin that vendor pages often lean on. Corpas E, et al. J Clin Endocrinol Metab. 1992;75(2):530–535. DOIPubMed 1379256