Home / Encyclopedia / Khavinson Bioregulators / Pielotax

MONOGRAPH No. 057

EVIDENCE BASEPreclinical

TYPE

Natural peptide complex (cytomedin)

SEQUENCE

Proprietary complex

CAS

Not assigned

EU STATUS

Research only

WADA

Not listed

MIN PURITY

Lab-specific

Khavinson Bioregulators

Pielotax — EU research guide.

Pielotax is a Khavinson-series peptide bioregulator formulated for renal cell gene expression, proposed to support kidney functional reserve in aging models. Like Chitomur and Ovagen, it is a natural tissue-derived complex rather than a single synthetic sequence.

Last reviewed: 2026-09-24

What is Pielotax?

What does the research show?

Published data is limited to in-vitro kidney cell culture studies and a rat kidney-injury model from the originating research group; no human study was found. No independent replication outside that group was found as of mid-2026.

EU legal status

Not approved as a medicine anywhere in the EU. Available only from a small number of specialist research vendors.

⚠ Renal research compounds deserve extra scrutiny given the kidney's role in clearing other substances from the body — this is a laboratory research compound only, with a narrow evidence base.

✓ Not yet tracked in PeptideCompare's price comparison. Verify any vendor's COA and sequence/identity claims directly before ordering — see our COA guide.

EVIDENCE SUMMARY

ANIMAL ONLY

Cell renewal in rat kidney cultures — In organotypic kidney cultures from young and old rats, a polypeptide complex from calf kidneys raised the proliferation marker Ki-67 and lowered the pro-apoptotic marker p53; the short peptides AED and EDL acted in the same direction but less strongly. These are marker results in cultured tissue from one research group, without functional kidney outcomes.

ANIMAL ONLY

Rat cisplatin kidney-injury model — In rats with cisplatin-induced acute renal failure, peptides (AED, EDL, AEDG and a kidney polypeptide complex) are reported to have normalised diuresis, creatinine, glomerular filtration rate and sodium reabsorption and to have reduced proteinuria, with EDL described as the most potent. The abstract-level source I could open does not state group sizes or name Pielotax.

NO HUMAN DATA

Human kidney data — No human study of Pielotax, or of the kidney polypeptide complex, was found in indexed literature. The page's own reference to Eastern European cohort data could not be confirmed, and independent replication outside the originating group was not found.

Molecular information

CAS number

Not assigned

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Potency retained over time

Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.

Freezer −20 °C

36+ mo

Stable · >95% potency

Fridge 4 °C

4-5 wks

In use · after recon

Room 20 °C

5-6 days

Avoid · increased loss

Warm 37 °C+

<1 day

Critical · rapid degradation

⚠ Modelled per compound from molecular structure — chain length, cyclisation, oxidation- and deamidation-prone residues and light sensitivity. Indicative only, not lab-measured per batch.

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References

Culture study of a calf-kidney polypeptide complex and the short peptides AED and EDL in aging kidney cells; markers of cell renewal (Ki-67, p53) and of tissue remodelling (MMP-14) shifted. In vitro only, and the brand name Pielotax is not used in the abstract. Khavinson VKh, Lin'kova NS, Polyakova VO, Durnova AO, Nichik TE, Kvetnoi IM. Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging. Bull Exp Biol Med. 2014;157(2):261-264. DOI
Organotypic kidney cultures from young and old rats treated with the calf-kidney polypeptide complex and AED or EDL; proliferation and apoptosis markers moved in the direction the authors call regenerative. Rat tissue in a dish, no functional or human outcome. Chalisova NI, Lin'kova NS, Nichik TE, Ryzhak AP, Dudkov AV, Ryzhak GA. Peptide regulation of cells renewal processes in kidney tissue cultures from young and old animals. Bull Exp Biol Med. 2015;159(1):124-127. DOI PubMed 26033601
Rat model of cisplatin-induced acute renal failure testing AED, EDL, AEDG and a kidney polypeptide complex, with improvements in renal function measures reported. Animal data only, group sizes not stated in the parts I could open, and Pielotax is not named. Zamorskii II, Shchudrova TS, Lin'kova NS, Nichik TE, Khavinson VKh. Peptides restore functional state of the kidneys during cisplatin-induced acute renal failure. Bull Exp Biol Med. 2015;159(6):736-739. DOI PubMed 26515176
Organ-derived polypeptide complexes, including one from kidneys, in organotypic cultures of young and old animals; increased Ki-67 and reduced p53 and caspase-3. Culture data only, species not specified in the abstract. Ryzhak AP, Chalisova NI, Lin'kova NS, Nichik TE, Dudkov AV, Kolchina NV, Ryzhak GA, Khalimov RI. Effect of polypeptides on cell proliferation and apoptosis during aging. Bull Exp Biol Med. 2017;162(4):534-538. DOI

Pielotax — EU research guide.

What is Pielotax?

What does the research show?

EU legal status

Molecular information

Pharmacokinetics

Potency retained over time

Pielotax is not yet in our price comparison

References

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