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Home / Encyclopedia / Khavinson Bioregulators / Cardiogen
MONOGRAPH No. 048
EVIDENCE BASEPreclinical
TYPE
Synthetic tetrapeptide bioregulator
SEQUENCE
Ala-Glu-Asp-Arg
CAS
Not assigned
EU STATUS
Research only
WADA
Not listed
MIN PURITY
≥98% HPLC
Khavinson Bioregulators

Cardiogen — EU research guide.

Cardiogen is a synthetic tetrapeptide (Ala-Glu-Asp-Arg) from the Khavinson bioregulator series, proposed to support cardiomyocyte metabolism and cardiovascular tissue maintenance. It is studied alongside other organ-specific short peptide bioregulators such as Vesugen (vascular) and Cortagen, which PeptideCompare already tracks.

Last reviewed:

What is Cardiogen?

Cardiogen is a synthetic tetrapeptide (Ala-Glu-Asp-Arg) from the Khavinson bioregulator series, proposed to support cardiomyocyte metabolism and cardiovascular tissue maintenance. It is studied alongside other organ-specific short peptide bioregulators such as Vesugen (vascular) and Cortagen, which PeptideCompare already tracks.

What does the research show?

The only primary study verified so far, from the originating Russian group, is a cell-culture experiment in mouse embryonic fibroblasts reporting higher expression of cytoskeletal and nuclear matrix proteins; no animal cardiac-model study and no human study of Cardiogen could be verified. Independent Western replication is minimal, and no peer-reviewed Phase-style human trials are publicly available as of mid-2026.

EU legal status

Not approved as a medicine anywhere in the EU. Available only from specialist research peptide vendors for laboratory research.

⚠ Cardiovascular research compounds carry obvious real-world stakes if misapplied. The verified evidence is preliminary, limited to cell-culture data, and has not been independently replicated at scale.
✓ PeptideCompare monitors Cardiogen across EU research suppliers. Verify any vendor's COA and sequence/identity claims directly before ordering — see our COA guide.
EVIDENCE SUMMARY
LIMITED
Structural protein expression in cultured cells — In cultured mouse embryonic fibroblasts, the Ala-Glu-Asp-Arg tetrapeptide raised expression of cytoskeletal proteins (actin, tubulin, vimentin) 2 to 5 fold and of nuclear matrix proteins (lamin A, lamin C) 2 to 3 fold. The authors link this to the peptide's reported cardioprotective properties, but the experiment used fibroblasts, not heart muscle cells.
NO HUMAN DATA
No verified animal-heart or human data — No cardiac animal model study and no human study of Cardiogen could be opened. Claims of improved cardiac tissue markers or recovery after cardiac stress therefore could not be checked against a source; the evidence base is one Russian-group cell-culture paper.

Molecular information

Molecular formula
C18H31N7O9
Molecular weight
489.5 g/mol
CAS number
Not assigned

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Potency retained over time

Each line is one storage condition: it starts at 100% and declines as potency is lost. Above the dotted 80% line the material is considered reliable — hover the chart for exact values.

Freezer −20 °C
36+ mo
Stable · >95% potency
Fridge 4 °C
5-7 mo
In use · post-recon
Room 20 °C
3-4 wks
Limited · moderate loss
Warm 37 °C+
2-3 days
Poor · rapid loss

⚠ Estimates modelled per component from molecular properties (chain length, cyclisation, oxidation- and deamidation-sensitive residues, light sensitivity). Indicative only — not lab-measured per batch.

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References

  1. Cell-culture study in mouse embryonic fibroblasts from the originating group. It shows higher expression of structural proteins after peptide exposure, but not in cardiomyocytes and not in an animal or person, and no independent replication was found. Khavinson VKh, Lin'kova NS, Polyakova VO, Kvetnoy IM, Benberin VV, D'yakonov MM, Titkov YuS. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med. 2012;153(4):559-562. DOIPubMed 22977870

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