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MONOGRAPH No. 073
TYPE
Amino acid derivative
MW
161.2 g/mol
CAS
541-15-1
EU STATUS
Food supplement (oral) · Research (injectable)
WADA
Not prohibited
MIN PURITY
≥99% HPLC
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L-Carnitine — EU research guide.

L-Carnitine is a naturally occurring amino acid derivative essential for the transport of long-chain fatty acids into mitochondria for beta-oxidation. It is one of the most extensively studied metabolic compounds in human nutrition and sports science.

Last reviewed:

What is L-Carnitine?

L-Carnitine is synthesised in the liver and kidneys from lysine and methionine, with vitamin C as a cofactor. It forms acylcarnitine esters with fatty acyl-CoA, allowing transport across the inner mitochondrial membrane via the carnitine shuttle. Without adequate carnitine, long-chain fatty acid oxidation is impaired. Injectable forms are used in clinical medicine for primary carnitine deficiency.

What does the research show?

Oral supplementation evidence for performance enhancement in healthy individuals is mixed; benefits are most clear in carnitine-deficient states (vegetarians, renal disease patients, elderly). Injectable L-carnitine shows more reliable bioavailability. Meta-analyses suggest modest improvements in fat oxidation, insulin sensitivity and recovery in specific populations. IV carnitine is used clinically for haemodialysis-related carnitine deficiency in the EU.

EU legal status

L-Carnitine is a legal food supplement in the EU (oral). Injectable research-grade L-carnitine is sold for laboratory and veterinary research. Injectable clinical preparations require prescription.

Oral supplementation benefits in healthy people are modest and dose-dependent. Injectable formulations require appropriate sterility standards. Not for human injection outside medical supervision. This is a research compound, not a medication.
✓ PeptideCompare lists injectable research-grade L-Carnitine from EU vendors. Ensure endotoxin testing (LAL) is documented for any injectable preparation.

Molecular information

Molecular formula
C7H15NO3
Molecular weight
161.2 g/mol
CAS number
541-15-1

Pharmacokinetics

Half-life (t½)
≈ 15 h
Source: Human PK (~15 h)

Potency retained over time

Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.

Freezer −20 °C
36+ mo
Stable · >95% potency
Fridge 4 °C
19-26 mo
In use · after recon
Room 20 °C
7-9 mo
Acceptable · slow loss
Warm 37 °C+
4-5 wks
Poor · accelerated loss

⚠ A structural estimate, derived from each compound's sequence length, cyclisation and oxidation-, deamidation- and light-sensitive residues. Indicative only — not lab-measured per batch.

L-Carnitine across EU suppliers

COA-verified EU vendors · Updated monthly

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