NAD+ synergists — what stacks with NMN and why.

Resveratrol is widely described as a direct SIRT1 activator, but that finding did not survive scrutiny: the apparent activation depended on a fluorophore attached to the assay substrate and disappears with native substrates. Any synergy with NAD+ therefore rests on less direct mechanisms than the usual “fuel and accelerator” picture suggests. Pterostilbene is the more bioavailable analogue with longer half-life. David Sinclair's core protocol includes 1g NMN + 1g resveratrol daily.

NMN metabolism consumes methyl groups. Without replenishment, you can deplete SAM (S-adenosylmethionine) — the body's primary methyl donor. TMG (500mg–1g/day) donates methyl groups to keep this pathway running and avoid potential side effects of NMN supplementation at higher doses.

A flavonoid that inhibits CD38 — the enzyme that degrades NAD+. CD38 increases significantly with age and is a major driver of NAD+ decline. Blocking it preserves more of the NAD+ you produce. Found in parsley, chamomile. Supplement dose: 50–100mg/day.

Both a CD38 inhibitor and a senolytic compound. Works synergistically with fisetin and dasatinib in senolytic protocols. Also has anti-inflammatory and antioxidant properties. Typical dose: 500–1000mg with EGCG or fisetin for senolytic effect.

Works alongside NAD+ in the mitochondrial electron transport chain. CoQ10 declines with age and with statin use. Ubiquinol (the reduced form) has better bioavailability than ubiquinone. If you're doing a serious mitochondrial protocol, CoQ10 200–400mg/day complements NMN well.

A mitochondria-derived peptide that activates AMPK and improves insulin sensitivity. Works in parallel with NAD+/sirtuin pathways to improve metabolic function. Available from several EU vendors — COA verified options tracked on PeptideCompare.