NAD+ synergists — what is studied alongside NMN and why.

Resveratrol is widely described as a direct SIRT1 activator, but that finding did not survive scrutiny: the apparent activation depended on a fluorophore attached to the assay substrate and disappears with native substrates. Any synergy with NAD+ therefore rests on less direct mechanisms than the usual “fuel and accelerator” picture suggests. Pterostilbene is the more bioavailable analogue with longer half-life.

NMN metabolism consumes methyl groups. Without replenishment, SAM (S-adenosylmethionine) — the body's primary methyl donor — can be depleted. TMG donates methyl groups, which is why it is discussed as a way to keep this pathway supplied.

A flavonoid that inhibits CD38 — the enzyme that degrades NAD+. CD38 increases significantly with age and is a major driver of NAD+ decline. Blocking it preserves more of the NAD+ you produce. Found in parsley, chamomile.

Both a CD38 inhibitor and a senolytic compound. It is studied together with fisetin and dasatinib in senolytic research. Also has anti-inflammatory and antioxidant properties.

Works alongside NAD+ in the mitochondrial electron transport chain. CoQ10 declines with age and with statin use. Ubiquinol (the reduced form) has better bioavailability than ubiquinone.

A mitochondria-derived peptide that activates AMPK and improves insulin sensitivity. Works in parallel with NAD+/sirtuin pathways to improve metabolic function. Available from several EU vendors — COA verified options tracked on PeptideCompare.