PeptideCompareTB-500 — Thymosin Beta-4 fragment.
TB-500 is a synthetic version of the active region of Thymosin Beta-4, a naturally occurring peptide involved in actin regulation, cell migration, and tissue repair.
- Synthetic active fragment of Thymosin Beta-4, a protein present in nearly all human cells.
- Primary mechanism is actin sequestration, central to cell migration and wound closure.
- Animal data support tissue repair, angiogenesis and reduced scarring, especially in cardiac-injury models.
- No completed human clinical trials; much popular interest derives from veterinary (equine) use.
- Research compound only and prohibited in sport; check whether you are buying the fragment or full-length Thymosin Beta-4.
What is TB-500?
TB-500 is the synthetic active fragment of Thymosin Beta-4, a 43-amino acid protein present in nearly all human cells. Its primary mechanism is actin sequestration — regulating the cytoskeleton protein actin, which is central to cell migration, wound closure and tissue repair. It is frequently researched alongside BPC-157 for complementary recovery mechanisms.
What does the research show?
What to look for when buying in Europe
TB-500 and the full-length Thymosin Beta-4 are sometimes sold interchangeably — check whether you are buying the fragment or the full peptide, as dosing differs. Require ≥98% HPLC purity and a batch-matched COA.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ A structural estimate, derived from each compound's sequence length, cyclisation and oxidation-, deamidation- and light-sensitive residues. Indicative only — not lab-measured per batch.
Compare TB-500 across EU suppliers
15 EU vendors · COA-verified · from €22.63 · Updated monthly
Frequently asked questions
What is TB-500? ▾
TB-500 is the synthetic active fragment of Thymosin Beta-4, a 43-amino-acid protein found in almost all human cells. It is studied for tissue repair through its effect on the cytoskeletal protein actin.
How does TB-500 work? ▾
Its main studied mechanism is actin sequestration — regulating actin, which drives cell migration, wound closure and tissue repair. It is also studied for promoting new blood-vessel formation.
Is TB-500 the same as Thymosin Beta-4? ▾
TB-500 is a fragment of the full Thymosin Beta-4 protein. Vendors sometimes sell them interchangeably, so confirm which one you are buying — the fragment and the full peptide differ.
Is there human evidence for TB-500? ▾
No completed human clinical trials exist. The evidence is animal-stage, and a substantial part of the popular interest comes from veterinary use in horses.
Is TB-500 legal and approved? ▾
It is not approved by any regulator and is sold as a research chemical for laboratory use only. It is also prohibited in professional sport.
What is TB-500 researched for? ▾
Animal studies look at wound healing, muscle and tendon repair, cardiac repair with reduced scarring, and angiogenesis. Hair-growth and anti-inflammatory signals are preliminary.
How do I check TB-500 purity? ▾
Require ≥98% HPLC purity on a batch-matched COA from a named lab, and confirm whether the product is the fragment or full-length Thymosin Beta-4.
Why is TB-500 often paired with BPC-157? ▾
Researchers combine them for complementary repair mechanisms. This reflects how the compounds are studied, not a recommended protocol — we do not provide dosing or administration advice.
References
- Rat study showing gastric pentadecapeptide and thymosin-class peptides accelerate transected Achilles tendon healing and stimulate tendocyte growth (context for actin-regulating repair peptides). Staresinic M, et al. J Orthop Res. 2003;21(6):976–983. DOI PubMed 14554209