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MONOGRAPH No. 091
EVIDENCE BASEStrong
SEQUENCE
15 amino acids
MW
1419.5 g/mol
CAS
137525-51-0
EU STATUS
Research only
WADA
Prohibited S0
MIN PURITY
≥98% HPLC
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🧬 Recovery & Healing

BPC-157 — complete EU guide.

Body Protection Compound-157 is a synthetic pentadecapeptide derived from a protein found in gastric juice. It is the most-searched research peptide in Europe.

Last reviewed:
Key findings at a glance
  • Synthetic 15-amino-acid partial sequence of a protein found in human gastric juice; unusually stable in gastric acid.
  • Most replicated findings are accelerated tendon-to-bone and ligament healing in animal models.
  • Strong rodent evidence for gastrointestinal mucosal protection — the research area where BPC-157 originated.
  • No completed human clinical trials; systemic and neurological claims rest on animal data only.
  • Banned in professional sport and not approved by any regulator; research compound only.

What is BPC-157?

BPC-157 is a synthetic peptide of 15 amino acids — a partial sequence of a protein found in human gastric juice. Unlike many research peptides it is stable in gastric juice, which explains interest in both oral and injectable forms. It is not an approved pharmaceutical anywhere and is sold by EU research vendors for laboratory research only.

What does the research show?

EVIDENCE SUMMARY
STRONG
Tendon & ligament healing — Multiple animal studies show significantly accelerated tendon-to-bone healing and ligament regeneration. The most replicated finding.
STRONG
Gastrointestinal protection — Protective effects on gut mucosa, ulcer healing and IBD models in rodents. Where BPC-157 research originated and is most robust.
MODERATE
Angiogenesis — Upregulates VEGFR2 and promotes blood vessel formation. Proposed mechanism behind many healing effects.
ANIMAL ONLY
Neurological & systemic recovery — Interesting animal data but no published human clinical trials as of mid-2026. Human extrapolation is speculative.
No completed human clinical trials. All efficacy data comes from animal studies. Human extrapolation is not scientifically validated. This is a research compound, not a medication.

What to look for when buying in Europe

Minimum purity ≥98% HPLC with mass-spec identity confirmation. Demand a batch-specific COA from a named third-party lab. Lyophilized BPC-157 is stable at room temperature for weeks but ships best with cold packs over longer distances.

✓ PeptideCompare tracks BPC-157 from 14 COA-verified EU vendors, starting from €18.85. Prices move month to month and differ by vendor; compare before ordering.

Molecular information

Molecular formula
C62H98N16O22
Molecular weight
1419.5 g/mol
CAS number
137525-51-0

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Compare BPC-157 across EU suppliers

14 EU vendors · COA-verified · from €18.85 · Updated monthly

Frequently asked questions

What is BPC-157?

BPC-157 is a synthetic peptide of 15 amino acids, a partial sequence of a body-protection compound found in human gastric juice. It is studied for tissue repair and gastrointestinal protection but is not an approved medicine anywhere.

Does BPC-157 actually heal injuries?

Animal studies consistently show accelerated tendon, ligament and gut healing, and tendon-to-bone repair is its most replicated finding. However, there are no completed human clinical trials, so human efficacy is not scientifically established.

Is BPC-157 approved or legal?

It is not approved by the FDA, EMA or any regulator. In most EU countries it is sold as a research chemical for laboratory use only, not for human or animal consumption.

Can BPC-157 be taken orally?

Because the parent compound is stable in gastric juice, both oral and injectable forms are discussed in the research. Oral stability is one reason it attracted interest, but human dosing data does not exist and we do not provide administration advice.

What does the gut research show?

Rodent models show protective effects on gastric mucosa, ulcer healing and inflammatory bowel models. This is the original and most robust area of BPC-157 research.

Is BPC-157 safe?

Animal studies report a favourable safety profile and only small human pilot reports exist. Without completed clinical trials, the human safety profile is not established.

Is BPC-157 banned in sport?

Yes. It appears on anti-doping prohibited lists and its use is banned in professional sport.

How do I verify BPC-157 quality?

Require a batch-specific COA from a named third-party lab showing ≥98% HPLC purity with mass-spec identity confirmation. Lyophilised BPC-157 is relatively stable but ships best cold over long distances.

Why is BPC-157 often researched with TB-500?

They are studied together for complementary tissue-repair mechanisms — BPC-157 for angiogenesis and gut/tendon effects, TB-500 for actin regulation and cell migration. This is a research observation, not a usage recommendation.

References

  1. Rat study showing BPC-157 promoted Achilles tendon-to-bone healing and counteracted corticosteroid-impaired healing. Krivic A, et al. J Orthop Res. 2006;24(5):982–989. DOI PubMed 16583442
  2. In-vitro work showing BPC-157 accelerates tendon fibroblast outgrowth, survival and migration via the FAK-paxillin pathway. Chang CH, et al. J Appl Physiol. 2011;110(3):774–780. DOI PubMed 21030672
  3. Systematic review of BPC-157 in orthopaedic sports medicine summarising preclinical efficacy and the lack of FDA approval. Vasireddi N, et al. HSS J. 2025;21(4):485–495. DOI PubMed 40756949

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