PeptideCompareN-Acetyl Epithalon Amidate — EU research guide.
N-Acetyl Epithalon Amidate is a modified version of Epitalon (Ala-Glu-Asp-Gly) with an acetyl group and amide cap added to its two ends — changes intended to improve stability, in the same way N-Acetyl variants of Selank and Semax modify their parent peptides.
What is N-Acetyl Epithalon Amidate?
Epitalon is a synthetic tetrapeptide studied for telomerase activation and pineal-gland/melatonin regulation. Adding an N-terminal acetyl group and C-terminal amide is a common peptide-engineering technique meant to resist enzymatic degradation from both ends of the chain, potentially extending activity duration compared with the unmodified peptide.
Research context
No published research on the acetylated/amidated variant specifically could be found, unlike for standard Epitalon itself, whose telomerase and pineal-function studies form the bulk of the evidence base referenced for this compound class.
EU legal status
Not an approved medicine; sold as a research chemical by RUO peptide suppliers.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ Modelled per compound from molecular structure — chain length, cyclisation, oxidation- and deamidation-prone residues and light sensitivity. Indicative only, not lab-measured per batch.
Longevity compounds across EU suppliers
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References
- A 2025 review of the parent peptide Epitalon (Ala-Glu-Asp-Gly). It describes limited human evidence and mostly cell and animal work, and it does not discuss acetylated or amidated variants. Useful for context on the parent only; it says nothing about this modified compound. Szeleszczuk et al. Overview of Epitalon - Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. DOI
- A laboratory study of the parent AEDG peptide in cultured human stem cells (cell culture only, no animals or people). It is included to show what kind of evidence exists for the parent; it does not concern the N-acetyl amidated variant. Khavinson V et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. DOIPubMed 32019204
- A chemical database entry for 'N-Acetyl Epitalon'. It identifies the compound and its formula, but a database record is not a study and contains no evidence of stability or effects that this guide could verify. National Center for Biotechnology Information. PubChem Compound Summary for CID 171390141, N-Acetyl Epitalon. Source