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Home / Encyclopedia / Anti-Aging & Longevity / N-Acetyl Epithalon Amidate
MONOGRAPH No. 129
TYPE
Modified Epitalon analogue
MW
Tetrapeptide derivative (modified)
CAS
Not assigned
EU STATUS
Not approved · Research
WADA
Not listed
MIN PURITY
≥98% HPLC
⏳ Anti-Aging & Longevity

N-Acetyl Epithalon Amidate — EU research guide.

N-Acetyl Epithalon Amidate is a modified version of Epitalon (Ala-Glu-Asp-Gly) with an acetyl group and amide cap added to its two ends — changes intended to improve stability, in the same way N-Acetyl variants of Selank and Semax modify their parent peptides.

Last reviewed:

What is N-Acetyl Epithalon Amidate?

Epitalon is a synthetic tetrapeptide studied for telomerase activation and pineal-gland/melatonin regulation. Adding an N-terminal acetyl group and C-terminal amide is a common peptide-engineering technique meant to resist enzymatic degradation from both ends of the chain, potentially extending activity duration compared with the unmodified peptide.

Research context

Independent published research on the acetylated/amidated variant specifically is far more limited than for standard Epitalon itself, whose telomerase and pineal-function studies form the bulk of the evidence base referenced for this compound class.

EU legal status

Not an approved medicine; sold as a research chemical by RUO peptide suppliers.

Limited independent research on this specific modified variant compared with standard Epitalon; most cited evidence pertains to the parent peptide.
✓ For the extensively studied parent compound, PeptideCompare tracks Epitalon from EU research vendors with COA documentation.

Molecular information

Molecular weight
Tetrapeptide derivative (modified)
CAS number
Not assigned

Pharmacokinetics

No established human pharmacokinetic data. Published human PK parameters for this compound are not available; reported data are limited to animal models or absent. No curve is shown, to avoid implying data that does not exist.

Longevity compounds across EU suppliers

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