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Home / Encyclopedia / GLP-1 & Weight / Semaglutide vs Retatrutide
⚖️ GLP-1 & Weight

Semaglutide vs Retatrutide

How do Semaglutide and Retatrutide compare for GLP-1 & Weight research? Side-by-side evidence, molecular profile, EU legal status and COA-verified supplier prices — never dosing advice.

At a glance

Semaglutide

⚖ GLP-1 & Weight
EVIDENCE BASEStrong
CLASS
GLP-1 agonist
DEVELOPER
Novo Nordisk
EU STATUS
EMA approved (pharma)
RESEARCH
Research use only
WADA
Prohibited S0
MIN PURITY
≥98% HPLC
Molecular weight
4113.58 g/mol
CAS number
910463-68-2
Route
Subcutaneous (weekly)
Half-life (t½)
≈7 days (~165 h)
Tmax
1–3 days
Bioavailability
≈89% (SC)
PRICE FROM
€64.95 · 4 EU vendors
View prices →

Retatrutide

⚖ GLP-1 & Weight
EVIDENCE BASEModerate
MECHANISM
GLP-1 · GIP · GCG
DEVELOPER
Eli Lilly
PHASE
Phase 3 (2024–)
CAS
2381090-02-2
EU STATUS
Research only
WADA
Prohibited S0
MIN PURITY
≥98% HPLC
Molecular weight
4731.4 g/mol
Route
Subcutaneous (weekly)
Half-life (t½)
≈6 days (~144 h)
Tmax
12–72 h
PRICE FROM
€44.49 · 21 EU vendors
View prices →

Which fits which research target?

Both Semaglutide and Retatrutide sit within GLP-1 & Weight research but are studied for different primary signals. Semaglutide exists as an EMA-authorised medicine (the licensed product is not the research vial sold by vendors), while Retatrutide is not an approved medicine — compare the evidence, not marketing claims.

PRIMARY RESEARCH SIGNAL
Semaglutide
Weight reduction
Retatrutide
Weight reduction
⚠ Retatrutide is not an approved medicine, and the licensed medicine of Semaglutide is not the research vial sold by vendors. All comparisons here are research observations, not usage, dosing or efficacy recommendations.

What the research shows

Semaglutide

EVIDENCE SUMMARY
STRONG
Weight reduction — STEP trial series: ~15% mean body weight reduction at 68 weeks. FDA/EMA approved for obesity (Wegovy).
STRONG
Glycemic control — SUSTAIN trial series. FDA/EMA approved for type 2 diabetes (Ozempic) since 2017/2018.
STRONG
Cardiovascular outcomes — SELECT trial (2023): significant reduction in major adverse cardiovascular events in overweight/obese patients.

Retatrutide

EVIDENCE SUMMARY
STRONG
Weight reduction — Phase 2 NEJM-published trial: up to 24.2% body weight reduction at 48 weeks at highest dose. Dose-dependent. Superiority to semaglutide and tirzepatide in head-to-head observations.
STRONG
Glycemic control — Significant HbA1c reductions across all dose groups in Phase 2. GLP-1 + GIP synergy well-established from tirzepatide data.
MODERATE
Metabolic markers — Improvements in lipid profiles, liver fat, and insulin sensitivity observed in Phase 2. Glucagon component may improve hepatic outcomes.
PHASE 3 PENDING
Long-term safety, cardiovascular outcomes — Phase 3 TRIUMPH trials ongoing as of 2026. Long-term safety profile not yet established to the same degree as approved GLP-1 drugs.

Compare prices across EU suppliers

Compare Semaglutide across EU suppliers

4 EU vendors · COA · from €64.95

View prices →

Compare Retatrutide across EU suppliers

21 EU vendors · COA · from €44.49

View prices →

Frequently asked questions

Is Semaglutide or Retatrutide better? ▾

Only Semaglutide exists as an EMA-authorised medicine, and “better” depends on the research target. Semaglutide is most associated with Weight reduction, while Retatrutide is studied for Weight reduction. Compare the evidence tiers and COA-verified EU pricing above rather than assuming one is superior. This is not a usage recommendation.

Why compare Semaglutide and Retatrutide? ▾

Both are studied within GLP-1 & Weight research through different mechanisms, so researchers often weigh them against each other. This page sets their evidence, molecular profile, EU legal status and supplier pricing side by side.

Which is cheaper in the EU, Semaglutide or Retatrutide? ▾

Prices vary by supplier, vial size and COA status. Semaglutide is listed from €64.95 across 4 COA-verified EU vendors; Retatrutide from €44.49 across 21. Open the price pages above to compare current listings — nobody pays us for placement.

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