PeptideCompareAOD-9604 — the HGH fat-loss fragment.
AOD-9604 is a modified fragment of the C-terminus of human growth hormone (amino acids 176-191), engineered to retain HGH’s fat-metabolising action without its growth-promoting or blood-sugar effects.
- Modified fragment of human growth hormone (amino acids 176–191) designed to isolate GH's fat-breakdown action.
- Does not raise IGF-1 or impair insulin sensitivity the way full HGH does.
- Animal studies show lipolysis and reduced fat accumulation, but the pivotal human Phase 2b obesity trial failed its primary weight-loss endpoint.
- Commercial obesity development was halted in 2007; a favourable safety profile was reported across ~900 trial participants.
- Not approved as a drug by any major regulator; research compound only.
What is AOD-9604?
AOD-9604 is the fat-loss fragment of human growth hormone with an added tyrosine. Native HGH stimulates fat breakdown (lipolysis) through its C-terminal region; AOD-9604 isolates this action. Crucially, it does not raise IGF-1 or affect insulin sensitivity the way full HGH does, which was the basis for its development as a potential anti-obesity agent.
What does the research show?
What to look for when buying in Europe
A relatively affordable HGH fragment. Confirm you are buying AOD-9604 specifically (not generic "HGH frag 176-191" which may differ in the added tyrosine). Require ≥98% HPLC purity.
Molecular information
Pharmacokinetics
Potency retained over time
Each line is one storage condition: it starts at 100% and falls as potency is lost. Above the dashed 80% line the material is considered reliable — hover for exact values.
⚠ A structural estimate, derived from each compound's sequence length, cyclisation and oxidation-, deamidation- and light-sensitive residues. Indicative only — not lab-measured per batch.
Compare AOD-9604 across EU suppliers
10 EU vendors · COA-verified · from €21.37 · Updated monthly
Frequently asked questions
What is AOD-9604? ▾
AOD-9604 is a synthetic fragment of human growth hormone (amino acids 176–191) with an added tyrosine, designed to isolate GH's fat-breakdown (lipolytic) action.
Does AOD-9604 cause weight loss? ▾
Animal studies show lipolysis and reduced fat gain, but the largest human Phase 2b obesity trial did not meet its primary weight-loss endpoint, and commercial obesity development was halted in 2007. Human weight-loss evidence is weak.
How is AOD-9604 different from full HGH? ▾
It isolates the fat-metabolism action of growth hormone without raising IGF-1 or affecting insulin sensitivity the way full HGH does.
Is AOD-9604 approved or safe? ▾
It is not approved as a drug by the FDA, EMA or TGA. Across roughly 900 trial participants its safety profile was reported as favourable, but lack of efficacy ended its development.
Is AOD-9604 the same as HGH fragment 176-191? ▾
They are closely related but not identical — AOD-9604 carries an N-terminal tyrosine modification. Confirm you are buying AOD-9604 specifically if that is what you intend.
What is AOD-9604 researched for now? ▾
Beyond fat metabolism, there has been preliminary interest in cartilage and joint (osteoarthritis) research.
How do I verify AOD-9604 quality? ▾
Require a batch-matched COA showing ≥98% HPLC purity from a named lab.
Is AOD-9604 banned in sport? ▾
Treat GH-related fragments cautiously — anti-doping rules cover growth-hormone-related compounds, so athletes should assume it is prohibited.
References
- Early metabolic characterisation of the synthetic lipolytic hGH fragment AOD-9604. Ng FM, et al. Horm Res. 2000;53(6):274–278. DOI PubMed 11146367