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Home / Encyclopedia / GLP-1 & Weight / Semaglutide vs Tirzepatide
⚖️ GLP-1 & Weight

Semaglutide vs Tirzepatide

How do Semaglutide and Tirzepatide compare for GLP-1 & Weight research? Side-by-side evidence, molecular profile, EU legal status and COA-verified supplier prices — never dosing advice.

At a glance

Semaglutide

⚖ GLP-1 & Weight
EVIDENCE BASEStrong
CLASS
GLP-1 agonist
DEVELOPER
Novo Nordisk
EU STATUS
EMA approved (pharma)
RESEARCH
Research use only
WADA
Prohibited S0
MIN PURITY
≥98% HPLC
Molecular weight
4113.58 g/mol
CAS number
910463-68-2
Route
Subcutaneous (weekly)
Half-life (t½)
≈7 days (~165 h)
Tmax
1–3 days
Bioavailability
≈89% (SC)
PRICE FROM
€64.95 · 4 EU vendors
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Tirzepatide

⚖ GLP-1 & Weight
EVIDENCE BASEStrong
MECHANISM
GLP-1 · GIP dual
DEVELOPER
Eli Lilly
FDA STATUS
Approved (Mounjaro)
EU STATUS
EMA approved (Mounjaro)
RESEARCH STATUS
Research use only
WADA
Prohibited S0
MIN PURITY
≥98% HPLC
Molecular weight
4813.45 g/mol
CAS number
2023788-19-2
Route
Subcutaneous (weekly)
Half-life (t½)
≈5 days (~120 h)
Tmax
8–72 h
Bioavailability
≈80% (SC)
PRICE FROM
€37.9 · 7 EU vendors
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Which fits which research target?

Both Semaglutide and Tirzepatide sit within GLP-1 & Weight research but are studied for different primary signals. Neither is an approved medicine — compare the evidence, not marketing claims.

PRIMARY RESEARCH SIGNAL
Semaglutide
Weight reduction
Tirzepatide
Weight reduction
Neither Semaglutide nor Tirzepatide is an approved medicine. All comparisons here are research observations, not usage, dosing or efficacy recommendations.

What the research shows

Semaglutide

EVIDENCE SUMMARY
STRONG
Weight reduction — STEP trial series: ~15% mean body weight reduction at 68 weeks. FDA/EMA approved for obesity (Wegovy).
STRONG
Glycemic control — SUSTAIN trial series. FDA/EMA approved for type 2 diabetes (Ozempic) since 2017/2018.
STRONG
Cardiovascular outcomes — SELECT trial (2023): significant reduction in major adverse cardiovascular events in overweight/obese patients.

Tirzepatide

EVIDENCE SUMMARY
STRONG
Weight reduction — SURMOUNT-1 trial: up to 22.5% body weight reduction at 72 weeks. FDA approved for obesity (Zepbound) in 2023.
STRONG
Glycemic control — SURPASS trial series: superior HbA1c reduction vs semaglutide in head-to-head. FDA approved for T2D (Mounjaro) in 2022.
STRONG
Cardiovascular outcomes — SURMOUNT-MMO cardiovascular outcomes trial data published 2025. Significant CV risk reduction.

Compare prices across EU suppliers

Compare Semaglutide across EU suppliers

4 EU vendors · COA · from €64.95

View prices →

Compare Tirzepatide across EU suppliers

7 EU vendors · COA · from €37.9

View prices →

Frequently asked questions

Is Semaglutide or Tirzepatide better?

Neither is an approved medicine, and “better” depends on the research target. Semaglutide is most associated with Weight reduction, while Tirzepatide is studied for Weight reduction. Compare the evidence tiers and COA-verified EU pricing above rather than assuming one is superior. This is not a usage recommendation.

Why compare Semaglutide and Tirzepatide?

Both are studied within GLP-1 & Weight research through different mechanisms, so researchers often weigh them against each other. This page sets their evidence, molecular profile, EU legal status and supplier pricing side by side.

Which is cheaper in the EU, Semaglutide or Tirzepatide?

Prices vary by supplier, vial size and COA status. Semaglutide is listed from €64.95 across 4 COA-verified EU vendors; Tirzepatide from €37.9 across 7. Open the price pages above to compare current listings — nobody pays us for placement.

Read the full guides

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