One place to compare every EU research peptide — price, purity, verification and stock — across all major European suppliers. Independent. Updated monthly. COA-verified data only.
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302+ live prices · 17 EU suppliers · COA-geverifieerde data · No ads · No sponsored rankings
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May 23, 2026
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EU suppliers
17 vendors
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24Peptides — the lab benchmark
No othere andere EU leverancier publiceert een COA voor elk product in het assortiment. 24Peptides test via Liquilabs: purity, value mg, endotoxinen, zware metalen en microbiologische integriteit — standaard, voor elke batch.
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Research use only — All products listed are research chemicals intended exclusively for in-vitro laboratory research by qualified professionals. Not for human or animal consumption, medical diagnosis, or therapeutic use. Price and COA data sourced from publicly available vendor websites. PeptideCompare.com is independent and not affiliated with any listed supplier.
INSIGHTS & RESEARCH
Knowledge worth knowing.
Independent research, honest analysis, and real stories from the EU peptide and longevity space.
⚠ SAFETY
Why social media gray vendors are a trap — and what I lost finding out.
Instagram DMs, Telegram groups, TikTok promotions — gray market peptide vendors are everywhere. Here's every reason to avoid them, from someone who lost hundreds of euros learning this lesson firsthand.
12 min read·May 2026
⚡
NAD+ SCIENCE
NMN tablet vs NAD+ injection — why the precursor wins.
How your body converts NMN into NAD+ step by step, and why oral NMN 500/1000mg outperforms direct NAD+ in most protocols.
8 min read · May 2026
🔬
NAD+ SCIENCE
All NAD+ precursors explained — NMN, NR, NA, NAM and more.
A complete guide to every NAD+ precursor, how they differ, what the research shows, and which is right for your protocol.
10 min read · May 2026
🤝
LONGEVITY
NAD+ synergists — what stacks with NMN and why.
Resveratrol, TMG, apigenin, quercetin — the compounds that amplify NAD+ and sirtuins. Evidence reviewed.
9 min read · May 2026
🧹
LONGEVITY
Senolytics & senomorphics — clearing zombie cells for longevity.
What senescent cells are, why they accumulate, and how compounds like fisetin and dasatinib+quercetin target them.
11 min read · May 2026
📄
SAFETY & QUALITY
What a real COA tells you — and what might be hiding in your peptides.
A deep dive into COA certificates: how to read them, which labs to trust, and what contaminants to watch for.
10 min read · May 2026
KNOWLEDGE HUBS
Longevity by category.
Deep dives into every major longevity category — what the science says, which compounds matter, and what to look for when buying in Europe.
🧬
ACTIVE
Peptides
BPC-157, TB-500, Retatrutide, GHK-Cu and 76 more — compared across 17 EU vendors.
80 compounds →
⚡
KNOWLEDGE HUB
NAD+ Precursors
NMN, NR, niacin and every pathway that raises intracellular NAD+.
3 articles →
🔑
KNOWLEDGE HUB
Sirtuin Activators
Resveratrol, pterostilbene, fisetin — the molecules that activate longevity genes.
1 article →
🧹
KNOWLEDGE HUB
Senolytics
Clearing zombie cells with fisetin, quercetin and dasatinib protocols.
1 article →
♻️
KNOWLEDGE HUB
Autophagy
Spermidine, berberine, rapamycin — triggering cellular self-cleaning for longevity.
Coming soon
🔋
KNOWLEDGE HUB
Mitochondrial
CoQ10, PQQ, MitoQ, SS-31 — restoring the powerhouses of the cell.
Coming soon
🌡️
KNOWLEDGE HUB
Hormesis
Controlled stress for resilience — cold, heat, fasting, rapamycin and low-dose toxins.
Coming soon
🔭
More coming
New categories added regularly. COA verification, product experience reviews, and longevity protocols in development.
ABOUT PEPTIDECOMPARE · NON-PROFIT
Built on honesty.
A non-profit community initiative providing free, independent information about EU research peptide suppliers. No ads. No rankings for sale. No ads. No commercial interests. Just independent, open information.
OUR MISSION
Why PeptideCompare exists
Researchers in Europe had no independent source of information about peptide suppliers. Every site that "compared" was built by a supplier themselves. Quality differences were enormous but invisible to buyers.
We decided to change that — as a non-profit, community-driven initiative. We order anonymously from suppliers, review COA documents from accredited labs, and publish the results openly and freely. This exists nowhere else in Europe.
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Independent
No supplier pays for a higher position. Rankings are fully algorithmic: 50% prijs, 35% purity, 15% COA.
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Verified
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Three levels of certainty
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Per supplier
We placed an anonymous real order. Identity, delivery time and packaging personally reviewed.
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Per product + strength
Lab document from an accredited independent lab reviewed. Purity %, value mg and batch date verified. COA older than 12 months = expired.
◆ Product Verified
Per product + strength + leverancier
Dit exacte product is persoonlijk gebruikt en a clear research effect was confirmed. Non-transferable. Not for sale.
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17 EU suppliers · 302+ price rows · 80 peptides — free, open and COA-verified.
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LEGAL & POLICY
Policy & Disclaimer
📅 Last updated: May 23, 2026
TABLE OF CONTENTS
General disclaimer & research-only beleid
Data accuracy & aansprakelijkheid
Affiliate policy & commerciële relaties
Privacy policy (AVG/GDPR)
Cookie policy
Suppliersbeleid
Legal contact
01
General disclaimer & research-only beleid
⚠ Belangrijk: Alle producten vermeld op PeptideCompare.com zijn uitsluitend bestemd voor wetenschappelijk onderzoek (research use only). Not for human or animal use. Not approved by EMA or FDA.
PeptideCompare.com is een onafhankelijk vergelijkingsplatform. Wij verkopen geen producten. By using this site you confirm dat u you are at least 18 years old en you are consulting information for research purposes only.
02
Data accuracy & aansprakelijkheid
Prijzen — periodiek gecontroleerd via directe scraping. Supplierssites zijn de definitieve autoriteit. COA-data — from accredited labs. Verlopen COA's (>12 maanden) automatically flagged. Foutieve data — via contact melden. We corrigeren binnen 48 uur.
03
Affiliate policy & commerciële relaties
PeptideCompare is a non-profit information initiative. We do not earn commissions, do not sell advertising, and have no commercial agreements with listed suppliers.
✓ Commissies beïnvloeden rankings nooit ✓ Every EU supplier with COA documentation can be listed — free of charge ✓ No premium placements, no sponsored sections — rankings are purely algorithmic
04
Privacy policy (AVG/GDPR)
PeptideCompare.com handelt conform de AVG/GDPR. Geen persoonlijke data verzameld tenzij contactformulier ingevuld. Contact form data is deleted after 90 days en not shared with third parties.
Only functional cookies (noodzakelijk voor werking). No advertising cookies. No social media tracking. PeptideCompare is completely ad-free.
06
Suppliersbeleid
Suppliers in de database confirm that submitted data is accurate en COA-documenten authentiek zijn van geaccrediteerde labs. PeptideCompare reserves the right to remove a supplier for demonstrably incorrect data.
Free basisvermelding for every EU supplier with verifiable COA documentation. Deleteing aanvragen via the contact form.
Belgian law van toepassing. Rechtbank Brussel. Last revision: May 23, 2026.
⚠ SAFETY · May 2026 · 12 min read
Why social media gray vendors are a trap — and what I lost finding out.
I lost several hundred euros buying peptides through Instagram DMs and Telegram groups. This is everything I learned, so you don't have to.
What is a gray vendor?
A gray vendor is any seller operating outside of a legitimate, traceable business structure. They typically operate through Instagram profiles, Telegram channels, Facebook groups, WhatsApp, or TikTok — and they accept payment via crypto, PayPal friends & family, or wire transfer to a personal account. They have no registered business, no fixed domain, and often no way to contact them if something goes wrong.
They're not always scammers in the traditional sense. Some actually ship a product. But the product could be anything — underdosed, mislabeled, contaminated, or simply not what you ordered. And you have absolutely no recourse.
10 reasons to never buy from a gray vendor
1.
No COA, ever. Legitimate labs cost money. Gray vendors skip this entirely. You have no idea what's in the vial — purity, identity, contaminants. Independent testing of gray market peptides regularly shows wrong products, dangerous impurities, or zero active compound.
2.
No refund, no recourse. Payment via crypto or PayPal F&F is irreversible by design. If you receive nothing, the wrong product, or something dangerous — you have no chargeback, no consumer protection, no recourse whatsoever.
3.
Counterfeit products are common. Gray vendors frequently relabel cheap compounds (or plain water) as expensive peptides like Retatrutide or MOTS-C. The price looks attractive because the product isn't real.
4.
Bacterial contamination risk. Legitimate manufacturers produce in sterile environments with endotoxin testing. Gray vendors produce in unknown conditions — basements, uncontrolled environments. Endotoxins from contamination cause severe immune responses.
5.
They disappear overnight. Gray vendor accounts get banned, Telegram channels go dark, Instagram profiles vanish. The vendor you ordered from today may not exist in 48 hours. Your order history, their contact info — gone.
6.
Fake reviews everywhere. The testimonials on Telegram and Instagram are trivially easy to fabricate. Paid actors, fake accounts, screenshots of invented conversations. There is no verification mechanism whatsoever.
7.
Your personal data is at risk. Giving your home address to an unregistered entity with no data protection obligations is a serious privacy risk. Your data can be sold, leaked, or used in ways you'd never consent to.
8.
Customs and legal exposure. Gray vendors often ship from outside the EU with no proper labeling. This creates customs complications and in some countries, legal exposure for the buyer. Legitimate EU vendors handle this properly.
9.
The "discount" isn't real. Gray vendors price below market because they're either selling underdosed product, skipping safety testing, or simply planning to take your money and ship nothing. Legitimate competition on price exists — PeptideCompare tracks it. The gray vendor "deal" is a different category entirely.
10.
You fund a harmful ecosystem. Every purchase from a gray vendor makes the space more dangerous for everyone. It funds operations that cut corners on safety, evade accountability, and undermine the legitimate vendors who invest in real COA testing and quality control.
THE ALTERNATIVE
The EU has 17+ legitimate research peptide vendors with real business registrations, independent COA testing, and actual recourse if something goes wrong. PeptideCompare lists and ranks all of them — with verified COA data, price comparisons, and independent reviews. Use them.
⚡ NAD+ SCIENCE · May 2026 · 8 min read
NMN tablet vs NAD+ injection — why the precursor wins.
NMN at 500–1000mg in tablet form is more practical, better absorbed, and more cost-effective than direct NAD+ for most protocols. Here is the science behind why.
How your body makes NAD+ from NMN — step by step
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of your body, essential for energy metabolism, DNA repair, and sirtuin activation. Levels decline significantly with age — by your 50s, you may have less than half the NAD+ you had at 20.
THE NAD+ BIOSYNTHESIS PATHWAY FROM NMN
1
NMN enters intestinal cells NMN (Nicotinamide Mononucleotide) is absorbed in the small intestine via the Slc12a8 transporter. Sublingual or encapsulated forms improve absorption rate.
2
NMN → NAD+ via NMNAT enzymes Inside cells, NMN is converted to NAD+ by NMNAT (Nicotinamide Mononucleotide Adenylyltransferase) enzymes. This reaction is fast and efficient inside target tissues.
3
NAD+ activates sirtuins (SIRT1–SIRT7) Higher intracellular NAD+ activates sirtuin deacylases, which regulate gene expression, mitochondrial biogenesis, inflammation, and DNA repair.
4
PARP activation for DNA repair NAD+ fuels PARP enzymes that detect and repair DNA strand breaks — a key mechanism in aging and cancer prevention.
5
Mitochondrial energy production NAD+ is the essential electron carrier in the mitochondrial electron transport chain — the process that generates ATP. Higher NAD+ = more efficient cellular energy.
Why not just inject NAD+ directly?
Direct NAD+ injection does raise blood NAD+ levels rapidly. But it comes with significant disadvantages:
Painful administration: IV NAD+ infusions are notorious for discomfort — flushing, chest tightness, nausea. High-dose injections require slow administration.
NAD+ doesn't cross cell membranes easily: Injected NAD+ in the bloodstream must be broken down and rebuilt inside cells anyway. The precursor route is more biologically direct.
Cost: NAD+ injections cost €50–150 per session. NMN 500mg tablets from a verified EU supplier cost €60–100 per month of daily dosing.
Convenience: Daily oral NMN is dramatically simpler to sustain than periodic injections.
500mg vs 1000mg — which dose?
Human clinical trials show measurable NAD+ increases at 250mg, with stronger effects at 500–1000mg. The Sinclair Lab uses 1g NMN daily. Most clinical protocols use 500mg as the standard dose with good tolerability. Start at 250–500mg and titrate up based on response. Take in the morning with food — NAD+ is energizing and may disrupt sleep if taken at night.
Bottom line:NMN 500–1000mg/day in tablet form is the most practical, evidence-backed way to raise intracellular NAD+. Direct NAD+ injections have a role in clinical settings but oral NMN wins on cost, convenience, and tolerability for daily use.
🔬 NAD+ SCIENCE · May 2026 · 10 min read
All NAD+ precursors explained — NMN, NR, NA, NAM and more.
Not all NAD+ precursors are equal. Here is a complete guide to every major precursor, how they differ biochemically, and what the evidence says about each.
NMN — NICOTINAMIDE MONONUCLEOTIDE
The most direct NAD+ precursor. Enters cells via dedicated transporters. Strong human clinical data. Expensive to produce, so quality varies enormously — always verify COA.
✓ Best evidence · High cost · Quality-sensitive
NR — NICOTINAMIDE RIBOSIDE
One step before NMN in the biosynthesis pathway. Well-studied, good safety profile, lower cost than NMN. Must be converted to NMN then NAD+ inside cells. Patented by ChromaDex (Tru Niagen).
✓ Good evidence · Medium cost · Well-tolerated
NA — NICOTINIC ACID (NIACIN)
The oldest NAD+ precursor, used clinically for decades for cholesterol. Highly effective at raising NAD+, very inexpensive. Major drawback: flushing at doses above 50–100mg. Slow-release forms mitigate this.
⚠ Effective · Very cheap · Flushing side effect
NAM — NICOTINAMIDE (NIACINAMIDE)
The amide form of niacin. No flushing. Raises NAD+ effectively. However, at high doses it inhibits sirtuins — counterproductive for longevity protocols. Best used at lower doses (250–500mg) combined with NMN.
⚠ No flushing · Cheap · Sirtuin inhibition at high dose
NAMN — NICOTINIC ACID MONONUCLEOTIDE
A newer precursor entering via the Preiss-Handler pathway. Early research suggests it may avoid NAMPT bottlenecks that limit NMN efficacy. Limited human data so far. Watch this space.
? Emerging · Limited data · Promising
DIHYDRONICOTINAMIDE RIBOSIDE (NRH)
A reduced form of NR that some studies show raises NAD+ more powerfully than NMN or NR in mice. Very new, limited human data. Not widely commercially available yet.
? Research stage · Exciting early data
Which precursor should you use?
For most people starting a NAD+ protocol: NMN 500mg/day is the best starting point — strongest direct evidence, good tolerability, increasingly competitive pricing from verified EU suppliers. If cost is the primary concern, NR is a well-validated alternative at lower cost. Avoid high-dose NAM if sirtuins are a priority.
🤝 LONGEVITY · May 2026 · 9 min read
NAD+ synergists — what stacks with NMN and why.
NMN raises NAD+. But NAD+ is only part of the longevity equation. These compounds amplify the effect — through sirtuins, methylation support, and mitochondrial synergy.
🍇
RESVERATROL / PTEROSTILBENE
Resveratrol activates SIRT1 directly and works synergistically with NAD+ — NAD+ provides the fuel, resveratrol pushes the accelerator. Pterostilbene is the more bioavailable analogue with longer half-life. David Sinclair's core protocol includes 1g NMN + 1g resveratrol daily.
✓ Strong sirtuin synergy · Take with fat for absorption
🧬
TMG — TRIMETHYLGLYCINE (BETAINE)
NMN metabolism consumes methyl groups. Without replenishment, you can deplete SAM (S-adenosylmethionine) — the body's primary methyl donor. TMG (500mg–1g/day) donates methyl groups to keep this pathway running and avoid potential side effects of NMN supplementation at higher doses.
✓ Essential methylation support · Often overlooked
🌿
APIGENIN
A flavonoid that inhibits CD38 — the enzyme that degrades NAD+. CD38 increases significantly with age and is a major driver of NAD+ decline. Blocking it preserves more of the NAD+ you produce. Found in parsley, chamomile. Supplement dose: 50–100mg/day.
✓ CD38 inhibitor · Preserves NAD+ · Low cost
🟡
QUERCETIN
Both a CD38 inhibitor and a senolytic compound. Works synergistically with fisetin and dasatinib in senolytic protocols. Also has anti-inflammatory and antioxidant properties. Typical dose: 500–1000mg with EGCG or fisetin for senolytic effect.
✓ Dual role: CD38 inhibitor + senolytic
⚡
CoQ10 / UBIQUINOL
Works alongside NAD+ in the mitochondrial electron transport chain. CoQ10 declines with age and with statin use. Ubiquinol (the reduced form) has better bioavailability than ubiquinone. If you're doing a serious mitochondrial protocol, CoQ10 200–400mg/day complements NMN well.
✓ Mitochondrial synergy · Take with fat
🔵
MOTS-C
A mitochondria-derived peptide that activates AMPK and improves insulin sensitivity. Works in parallel with NAD+/sirtuin pathways to improve metabolic function. Available from several EU vendors — COA verified options tracked on PeptideCompare.
✓ Mitochondrial peptide · AMPK activation
🧹 LONGEVITY · May 2026 · 11 min read
Senolytics & senomorphics — clearing zombie cells for longevity.
Senescent cells accumulate with age, releasing inflammatory signals that damage surrounding tissue. Senolytics clear them. Senomorphics neutralize them. Here is everything you need to know.
What are senescent cells?
Senescent cells — often called "zombie cells" — are cells that have stopped dividing but refuse to die. They accumulate with age, after DNA damage, or after cellular stress. Rather than undergoing apoptosis (programmed cell death) they enter a permanent arrested state and begin secreting a toxic cocktail of inflammatory cytokines, proteases, and growth factors known as SASP (Senescence-Associated Secretory Phenotype).
SASP damages neighboring cells, promotes chronic inflammation, impairs tissue regeneration, and drives many hallmarks of aging: fibrosis, immune decline, metabolic dysfunction, and increased cancer risk. By the time you're 60-70, senescent cells may constitute a significant fraction of certain tissues.
Senolytics vs senomorphics
SENOLYTICS
Kill senescent cells selectively. Target anti-apoptotic pathways that allow zombie cells to survive. Used in intermittent protocols (not daily) — typically one 2-day cycle per month.
Do not kill senescent cells, but suppress SASP — reducing the inflammatory signals they release. Can be used daily. Lower risk profile than true senolytics.
Dasatinib + Quercetin (D+Q) — the most-studied senolytic combination. Dasatinib is an FDA-approved cancer drug that has shown remarkable senolytic activity in human trials. Quercetin enhances its effect and reduces side effects. Protocol: 100mg D + 1000mg Q for 2 consecutive days per month. Requires physician involvement for dasatinib.
Fisetin — a flavonoid with potent senolytic activity in animal models and early human data. Mayo Clinic conducted the first human trial. Protocol: 20mg/kg for 2 consecutive days. Fisetin also extends healthspan in mice significantly — one of the most promising OTC senolytics.
Navitoclax (ABT-263) — a BCL-2/BCL-XL inhibitor with strong senolytic activity. Not available OTC — clinical trial compound. Mentioned for completeness in the research landscape.
Connection to peptides
Several peptides on PeptideCompare work synergistically with senolytic protocols. BPC-157 supports tissue regeneration after senolytic clearance. MOTS-C improves the metabolic environment that drives senescence accumulation. Epitalon has shown telomere-stabilizing effects in research. GHK-Cu promotes tissue repair and has anti-inflammatory properties that complement senolytic protocols.
📄 SAFETY & QUALITY · May 2026 · 10 min read
What a real COA tells you — and what might be hiding in your peptides.
A Certificate of Analysis is only as good as the lab that issued it. Here is how to read one, which labs to trust, what to look for, and what contaminants are actually found in substandard peptides.
What is a COA?
A Certificate of Analysis (COA) is a document issued by an analytical laboratory confirming the composition and purity of a batch of product. For research peptides, a proper COA should include: identity confirmation (HPLC, LC-MS), purity percentage, actual assay content (mass in mg vs nominal), and ideally endotoxin and heavy metal testing.
COA red flags — how to spot a fake or weak COA
⚠
Issued by the Chinese manufacturer — Not independent. The supplier tested their own product. Meaningful only for batch consistency, not purity verification.
⚠
No identity test (only HPLC, no LC-MS) — HPLC measures purity but cannot confirm identity. LC-MS (mass spectrometry) confirms the molecule is actually what it claims to be. A COA without LC-MS cannot rule out deliberate mislabeling.
⚠
No batch number or date — A COA without a specific batch number and test date is effectively generic. It may not correspond to the actual product you receive.
⚠
No actual assay value (value mg) — A COA should state how many mg of active compound are actually present. A 10mg vial with 85% purity contains 8.5mg of active peptide. If the COA only shows 99% purity without an absolute mass, it's incomplete.
⚠
More than 12 months old — PeptideCompare automatically marks COAs older than 12 months as expired. Peptides degrade. An old COA gives no information about the current batch.
Trusted independent labs
✓ JANOSHIK
Czech lab. Most commonly used by EU suppliers. Offers HPLC and LC-MS. Results available on their website with QR verification.
✓ LIQUILABS
Specialized in peptide and research compound testing. Known for thorough endotoxin testing. Used by 24Peptides — results verifiable online.
✓ VLAB
European accredited laboratory with ISO certification. Offers comprehensive peptide panels including heavy metals and microbial contamination.
✓ COLMAR / ROTTAPHARM
High-tier pharmaceutical-grade labs. COAs from these labs represent the highest standard of verification available in Europe.
What contaminants are actually found?
Wrong peptide (mislabeling) — Independent testing of gray market and low-tier vendors regularly discovers completely different peptides than labeled. A vial sold as "Retatrutide" may contain semaglutide or a generic compound.
Endotoxins (bacterial lipopolysaccharides) — Present in improperly manufactured peptides. Cause immune activation, fever, inflammation. The EU standard limit is <0.001 EU/mg.
Heavy metals (lead, arsenic, mercury) — Contamination from synthesis reagents or equipment. Can accumulate in tissue. Only detected with specific heavy metal panels.
Acetate/TFA salt content — Peptides are often synthesized with TFA (trifluoroacetic acid) as a counterion. Residual TFA at high levels is cytotoxic. Better suppliers use acetate salt forms or perform TFA removal.
Underdosing — A 10mg vial with only 6mg of active compound. Without an assay value on the COA, you would never know.
HOW PEPTIDECOMPARE USES COA DATA
Every COA in our database is reviewed by our team. We verify the lab, check the batch date, confirm the assay value exists, and flag any COA older than 12 months as expired. COA purity contributes 35% to our ranking score — it's the second-most important factor after price.
🧬 CATEGORY HUB
Research Peptides
The most data-rich category on PeptideCompare — 80 peptides, 17 EU vendors, 302+ live price rows. All COA-verified.
80
PEPTIDES TRACKED
17
EU VENDORS
302+
PRICE ROWS
TOP CATEGORYS
🔄 Recovery & RepairBPC-157, TB-500, Wolverine
⚖️ GLP-1 / WeightRetatrutide, Tirzepatide, Sema
🧠 Neuro / CognitiveSemax, Selank, DSIP
⏳ Anti-AgingEpitalon, GHK-Cu, MOTS-C
⚡ Energy & MetabolicNAD+, SS-31, SLU-PP-332
VERIFICATION SYSTEM
✦ CMI Verified — Real anonymous order placed
✔ COA Verified — Lab document reviewed per product
NAD+ is essential for energy, DNA repair and sirtuin activation. It declines by up to 50% by age 50. These are the compounds that raise it back up.
THE PATHWAY AT A GLANCE
NMN
→
NR
→
NAM
→
NA (Niacin)
all convert to
NAD+
NMN — BEST EVIDENCE
★ Recommended
Most direct precursor. Strong human clinical trials. Dose: 500–1000mg/day in the morning. Quality varies — always verify COA purity and assay value.
Cost range: €60–120/month · Take with fat
NR — WELL STUDIED
One step before NMN in the pathway. Good safety profile, lower cost. Must convert to NMN then NAD+ inside cells. Patented form: Tru Niagen.
Cost range: €40–80/month · Good tolerability
NIACIN (NA) — CHEAPEST
Highly effective at raising NAD+. Very inexpensive. Major drawback: skin flushing at doses above 50mg. Slow-release forms reduce this. Clinically proven for decades.
Cost range: €5–15/month · Flushing side effect
NIACINAMIDE (NAM) — CAUTION
No flushing. Raises NAD+ but inhibits sirtuins at high doses — counterproductive for longevity. Best at low dose (250–500mg) alongside NMN, not as primary precursor.
⚠ Sirtuin inhibition at high dose
ARTICLES IN THIS HUB
NMN tablet vs NAD+ injection — why the precursor wins
8 min · Biosynthesis pathway step by step
→
All NAD+ precursors explained — NMN, NR, NA, NAM and more
10 min · Complete precursor comparison
→
NAD+ synergists — what stacks with NMN and why
9 min · Resveratrol, TMG, apigenin, quercetin
→
🔑 KNOWLEDGE HUB
Sirtuin Activators
Sirtuins are a family of 7 proteins (SIRT1–SIRT7) that regulate longevity, DNA repair, inflammation, and metabolism. They require NAD+ to function — and they can be activated by specific compounds.
SIRT1 & SIRT2
Nuclear sirtuins. SIRT1 regulates gene expression, inflammation and circadian rhythm. Activated by resveratrol, NAD+, and caloric restriction.
SIRT3, SIRT4 & SIRT5
Mitochondrial sirtuins. SIRT3 protects against oxidative stress and improves mitochondrial efficiency. Key target for longevity interventions.
SIRT6 & SIRT7
DNA repair and metabolic regulation. SIRT6 overexpression extends lifespan in mice. One of the most exciting longevity targets in current research.
KEY SIRTUIN ACTIVATORS
🍇
Resveratrol — the original sirtuin activator
Activates SIRT1 directly. Works synergistically with NAD+. Famously part of David Sinclair's protocol at 1g/day. Must be taken with fat for absorption. Pterostilbene is the more bioavailable, longer-lasting analogue.
🌼
Fisetin — senolytic and sirtuin activator
A flavonoid with dual action: SIRT1 activation and senolytic activity. One of the most potent compounds in the longevity stack. Human trials ongoing at Mayo Clinic.
🌿
Apigenin — SIRT1 activator & CD38 inhibitor
Inhibits CD38 (which breaks down NAD+) while activating SIRT1. Found in chamomile and parsley. At 50–100mg/day it preserves NAD+ and amplifies sirtuin activity.
🧬
NMN / NAD+ — the fuel sirtuins run on
Without NAD+, sirtuins cannot function regardless of how many activators you take. NAD+ is the essential cofactor — activators without adequate NAD+ levels have limited effect.
Read: NAD+ synergists — what stacks with NMN and why
Covers resveratrol, apigenin, quercetin and more in detail
→
🧹 KNOWLEDGE HUB
Senolytic & Senomorphic
Senescent "zombie" cells accumulate with age and release toxic inflammatory signals. Senolytics clear them. This is one of the most exciting areas in longevity science.
SENOLYTICS — KILL ZOMBIE CELLS
Selectively induce apoptosis in senescent cells. Used intermittently — typically one 2-day cycle per month or quarter, not daily.
🔴 Dasatinib + Quercetin (D+Q)
🌼 Fisetin (20mg/kg, 2-day cycles)
🟡 Quercetin (high dose, intermittent)
SENOMORPHICS — SUPPRESS SASP
Do not kill senescent cells but suppress the inflammatory signals they release (SASP). Can be used daily. Lower risk profile.
Full deep dive including D+Q protocol and peptide synergies
→
PEPTIDE CONNECTION
After senolytic clearance, your body needs to regenerate tissue. BPC-157 supports tissue repair, GHK-Cu promotes regeneration, and MOTS-C improves the metabolic environment that drives senescence accumulation. Many researchers combine senolytic cycles with peptide protocols for this reason.
♻️ KNOWLEDGE HUB
Autophagy Inducers
Autophagy is the cell's self-cleaning system — it breaks down and recycles damaged proteins and organelles. Declining autophagy is a core hallmark of aging. These compounds restore it.
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Spermidine
One of the most well-studied autophagy inducers. Found naturally in wheat germ, cheese, soy. As a supplement, 5–10mg/day. Human studies show improved cardiovascular and cognitive markers. Accessible, low risk.
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Rapamycin (mTOR inhibitor)
The most potent known autophagy inducer. mTOR inhibition drives autophagy powerfully. Used in longevity protocols at low intermittent doses (2–6mg weekly). Prescription only in most countries. Physician guidance essential.
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Berberine
AMPK activator with autophagy-inducing properties. Often called "natural metformin." Well-studied for metabolic health. 500–1000mg/day with meals. Widely available OTC in Europe.
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Intermittent Fasting
The most accessible autophagy trigger — no compounds needed. 16–24 hours of fasting meaningfully upregulates autophagy. Combines powerfully with spermidine and other inducers.
COMING SOON
Full autophagy article in development — covering the mTOR/AMPK balance, optimal fasting windows, and the peptide stack that complements autophagy cycles.
🔋 KNOWLEDGE HUB
Mitochondrial Support
Mitochondria are the energy powerhouses of every cell. Mitochondrial dysfunction is central to aging. These compounds restore function, efficiency and biogenesis.
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CoQ10 / Ubiquinol
Essential electron carrier in the mitochondrial respiratory chain. Declines with age and statin use. Ubiquinol (reduced form) has superior bioavailability. 200–400mg/day with fat.
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MitoQ
Mitochondria-targeted antioxidant. CoQ10 conjugated to a carrier that concentrates it specifically inside mitochondria — 1000x more potent than regular CoQ10 at the mitochondrial level.
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SS-31 (Elamipretide)
A mitochondria-targeted peptide available on PeptideCompare. Protects cardiolipin — the key structural lipid of the inner mitochondrial membrane. Profound effects on energy production in research.
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MOTS-C
A peptide encoded in mitochondrial DNA itself. Activates AMPK, improves insulin sensitivity, and enhances mitochondrial efficiency. Available COA-verified from multiple EU vendors on PeptideCompare.
The mitochondrial stack: NAD+ (via NMN) + CoQ10 + MOTS-C + SS-31 addresses mitochondrial function from multiple angles simultaneously — substrate availability, electron transport efficiency, structural integrity and AMPK activation.
🌡️ KNOWLEDGE HUB
Hormesis — Stress for strength.
Hormesis is the principle that low doses of stress make biological systems stronger. Cold, heat, fasting, exercise and certain compounds all trigger hormetic responses that drive longevity pathways.
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Cold exposure
Cold showers or ice baths activate norepinephrine, brown fat thermogenesis and mitochondrial biogenesis. 2–4 minutes at cold temperatures daily is sufficient for hormetic effect.
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Heat / Sauna
Regular sauna use is one of the most well-evidenced longevity interventions. Activates heat shock proteins, improves cardiovascular function, reduces all-cause mortality in epidemiological studies.
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Intermittent fasting
Caloric restriction and fasting trigger AMPK, autophagy, and sirtuin activation simultaneously. 16:8 or 24-hour fasts create powerful hormetic signaling across multiple longevity pathways.
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Pharmacological hormesis
Low-dose rapamycin (mTOR inhibition), low-dose lithium, low-dose naltrexone — compounds that at low doses trigger protective adaptive responses. All require physician guidance.
COMING SOON
Full hormesis article in development — covering the dose-response principle, optimal protocols for cold and heat, and how peptides like BPC-157 and TB-500 interact with hormetic stress adaptation.